FRC Guided Therapy in Acute Respiratory Failure

University of Luebeck

Status and phase: Unknown; Phase 4

Conditions: Cardiac Surgery; Mechanical Ventilation; Acute Respiratory Failure

Treatments: Procedure: alveolar recruitment manoeuvre

Study type: Interventional

Funder types: Other

Identifiers

NCT01280019

FRC-ARF

Details and patient eligibility

About

In ventilated patients with acute respiratory failure endotracheal suctioning may lead to alveolar derecruitment, which can be monitored by means of functional residual capacity (FRC) measurements. Regional distribution of ventilation can be followed at bedside using electrical impedance tomography. The investigators hypothesize that a FRC guided recruitment strategy, aimed at restoring a baseline FRC value after open endotracheal suctioning, improves oxygenation and regional distribution of ventilation. In addition the investigators research the impact of such a strategy on the inflammatory response to mechanical ventilation.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• need for mechanical ventilation due to respiratory failure after cardiac surgery

Exclusion criteria

• circulatory failure, eg. need for high doses of inotropes or extracorporal cardiac support

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

20 participants in 2 patient groups

FRC guided

Experimental group

Description:

Patients receive an alveolar recruitment manoeuvre if FRC falls below 94% of baseline FRC

Treatment:

Procedure: alveolar recruitment manoeuvre

Saturation guided

Active Comparator group

Description:

Patients receive an alveolar recruitment manoeuvre if peripheral oxygen saturation falls below 90%

Treatment:

Procedure: alveolar recruitment manoeuvre