Frequency and Clinical Significance of Renal and Bone Toxicity in HIV-infected Patients (ComorVIH)

Asociacion para el Estudio de las Enfermedades Infecciosas

Status: Completed

Conditions: Renal Toxicity

Study type: Observational

Funder types: NETWORK

Identifiers

NCT02116751

EC 039/14

Details and patient eligibility

About

The purpose of this study is to determine the frequency of renal and bone toxicity in HIV infected patients receiving antiretroviral therapy, and the outcome in terms of treatment change or/and virological failure, in relation with the presence of classical factors, such as diabetes or hypertension, the role of HIV itself, because of chronic inflammation, and the effects of antiretroviral medication.

Full description

This is a retrospective cohort study involving 300 patients to determine the frequency of renal and bone comorbidities/toxicity in a large population of HIV-infected patients receiving antiretroviral therapy, in order to establish the differential role of classical factors, HIV infection, or antiretroviral therapy.

Enrollment: 306 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Confirmed HIV infection

Exclusion criteria

• Pregnancy
• Prior therapy with antineoplastic chemotherapy or chronic treatment with corticosteroids
• Previous chronic therapy with antiresorptive bone therapy