Frequency of Diagnostic Symptomatic Pulmonary Embolism's in Patients Hospitalized for Clinical Exacerbation of Chronic Obstructive Pulmonary Disease (COPD) (PEP)

Regional University Hospital Center (CHRU)

Status: Completed

Conditions: Chronic Obstructive Pulmonary Disease; Patients Hospitalized for a COPD Exacerbation

Treatments: Other: PEP

Study type: Interventional

Funder types: Other

Identifiers

NCT02035293

RB 13-087 [CHRU Brest]

PEP

Details and patient eligibility

About

A standardized diagnostic strategy of pulmonary embolism will be applied to eligible patients, incorporating a clinical probability score (revised Geneva score), plasma D-dimer assay and if necessary, a multidetector-row CT angiography thoracic and venous ultrasound of the lower limbs. All the patient with a pulmonary embolism diagnosed or not, will be followed for 3 months.

Enrollment: 750 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients hospitalized for a COPD exacerbation
• COPD previously diagnosed

Exclusion criteria

• Allergy to iodinated contrast
• Creatinine clearance < 30 mL / min
• Patient hospitalized for exacerbation of COPD for more than 48 hours
• Pneumothorax
• Exams impossible to be performed
• Pregnancy
• Life expectancy < 3 months
• Patients already receiving anticoagulant therapy for another reason (mechanical valve, cardiac arrhythmia).

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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750 participants in 1 patient group

PEP

Other group

Description:

No drug and no placebo were used in this study. For all the patients who participated at the study PEP, only following exams must be performed: a clinical probability score (revised Geneva score), plasma D-dimer assay and if necessary, a chest multidetector-row CT angiography and venous ultrasound of the lower limbs

Treatment:

Other: PEP