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Frequent Activity Snacks Breaks (FABS)

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Karolinska Institute

Status

Completed

Conditions

Insulin Resistance
Obesity
Sedentary Lifestyle

Treatments

Procedure: muscle and fat biopsy
Behavioral: Normal lifestyle
Device: Continuous glucose monitoring
Device: Activity monitoring (ActivePal)
Behavioral: Exercise

Study type

Interventional

Funder types

Other

Identifiers

NCT03083587
2016/1768

Details and patient eligibility

About

There is a growing health burden in Sweden and Europe arising from the interrelated sequelae of metabolic disorders comprising impaired glucose tolerance (IGT), obesity and T2DM. Obesity and inactivity are the main drivers of IGT and T2DM and are responsible for up to 8% of health costs and 13% of deaths in Europe, with the risk of co-morbidities rising in parallel with increasing body weight. IGT and T2DM are the paradigm of inactivity-related disorders: the majority of people who have IGT or T2DM are overweight and inactive, with up to 80% being obese. A recent meta-analysis of 42 studies concluded that sedentary time was independently associated with a greater risk of T2D, all-cause mortality, cardiovascular disease incidence and mortality, and cancer incidence and mortality (breast, colon, colorectal, endometrial and epithelial ovarian cancers) (Ann Intern Med. 2015;162:123-32). A recent systematic review of trials published up to April 2014 identified 16 separate studies and concluded that there is considerable evidence of the positive effects of breaking up prolonged sitting time with light-intensity ambulatory physical activity and standing on postprandial metabolic parameters, including glucose, insulin and triglyceride levels (Med Sci Sports Exerc. 2015:47:2053-61). However, to date, all of the published experimental trials describing the beneficial effects of breaking up sitting time on metabolic risk markers have been restricted to acute exposure periods (1-5 days). We will perform a RCT intervention study, which examines the efficacy (clinically relevant responses) and practical implementation of low-impact training in sedentary obese individuals during the day.

Enrollment

20 patients

Sex

All

Ages

18 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Sedentary lifestyle,
  • BMI 30-40 kg/m2

Exclusion criteria

  • Unable to read Swedish (for informed consent),
  • anticoagulant therapy,
  • unability to perform intervention

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

20 participants in 2 patient groups

No intervention
Active Comparator group
Description:
Normal lifestyle. Subjects will undergo a muscle and fat biopsy at the start of the 4 w period and after. An oral glucose test at the start and after completion of the 4 week period. Physical activity and glucose will be monitored during the study period.
Treatment:
Device: Activity monitoring (ActivePal)
Behavioral: Normal lifestyle
Procedure: muscle and fat biopsy
Device: Continuous glucose monitoring
Exercise intervention
Experimental group
Description:
Followed by a 1 week normal run in period subjects will undergo a 3 min bout, every half hour between 8 am and 6 pm comprises of simple low-intensity exercise such as moderate walking about or climbing a flight of stairs over a 3-week period. Subjects will undergo a muscle and fat biopsy at the start of the 4 w period and after. An oral glucose test at the start and after completion of the 4 week period. Physical activity and glucose will be monitored during the study period.
Treatment:
Device: Activity monitoring (ActivePal)
Procedure: muscle and fat biopsy
Behavioral: Exercise
Device: Continuous glucose monitoring

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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