From Uncomplicated Alcoholism to Korsakoff's Syndrome (ALCOBRAIN)

Caen University Hospital

Status: Unknown

Conditions: Alcoholism; Alcohol Amnestic Disorder

Treatments: Biological: blood draw; Other: Brain imaging examination; Behavioral: Neuropsychological testing; Genetic: genetic testing

Study type: Interventional

Funder types: Other

Identifiers

NCT01455207

11-050

2011-A00495-36

Details and patient eligibility

About

This research project aims to identify factors that contribute to the heterogeneity observed in neuroradiological and neuropsychological signs of chronic alcoholism. The investigators overarching hypothesis is that the heterogeneity of alcoholic consequences on brain structure and metabolism, and cognition is mainly related to individual differences in pattern of alcohol use, gene pool, nutritional status and history of withdrawal symptoms.

Enrollment: 220 estimated patients

Sex: All

Ages: 21 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Completed at least 8 years of education (primary school equivalent)
• Age-normal corrected hearing and visual acuity

Exclusion criteria

• documented loss of consciousness of over 30 minutes, documented compound skull fracture, or clear neurological sequelae of head trauma
• history of medical or neurological illness or trauma potentially affecting the CNS, e.g., stroke, multiple sclerosis, epilepsy, psychosurgery, insulin coma.
• active tuberculosis or history of or any malignancy requiring chemotherapy
• history of schizophrenia or bipolar disorder
• metal implantation (e.g., pacemakers) or other factors that preclude MRI scanning for subjects selected for the neuroimaging examination
• meet DSM-IV criteria for current (past 3 months) other Substance Abuse
• met DSM-IV criteria for other Substance Dependence
• Have used other substances more than 5 times in the past month

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

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220 participants in 3 patient groups

alcoholic patients

Other group

Treatment:

Genetic: genetic testing

Biological: blood draw

Behavioral: Neuropsychological testing

Other: Brain imaging examination

korsakoff patients

Other group

Treatment:

Genetic: genetic testing

Biological: blood draw

Behavioral: Neuropsychological testing

Other: Brain imaging examination

healthy controls

Other group

Treatment:

Genetic: genetic testing

Biological: blood draw

Behavioral: Neuropsychological testing

Other: Brain imaging examination