Frontal Lobe Oxyhemoglobin Levels in Patients With Lower Extremity Burns Assessed Using a fNIRS

Hangang Sacred Heart Hospital

Status: Completed

Conditions: Walking

Treatments: Diagnostic Test: Functional near-infrared spectroscopy (fNIRS)

Study type: Interventional

Funder types: Other

Identifiers

NCT03990831

HangangSHH-1

Details and patient eligibility

About

Investigators investigate the patterns of cortical activation using the NIRST in patients with peripheral neurological injury caused by lower extremity burns.

Full description

Understanding the mechanisms associated with locomotor networks may be of benefit for rehabilitation of burn victims with neurological locomotor deficits. However, the effects of peripheral neurological injury on locomotor network remains unknown. A wearable functional near-infrared spectroscopy (fNIRS) device has been developed for studying cortical hemodynamics. Changes in cortical activity has not previously been documented in patients with burn injury.

Investigators assessed 15 patients with lower extremity burns and 11 healthy controls.

Investigators measured walking-related cortical activity using an fNIRS device at baseline and during usual walking.

Cortical activity was measured by evaluating relative changes in oxyhemoglobin level. The NIRST Analysis Tool v2.1 was utilized to analyze fNIRS data in a MATLAB environment.

Enrollment: 36 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• burn patients with lower extremity or upper extremity thermal injury
• patients who could walk unassisted for at least 5min.

Exclusion criteria

• patients with critical systemic conditions
• severe cognitive impairment
• had severe pain
• unable to walk.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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36 participants in 1 patient group

burn injury and normal patient

Other group

Description:

HbO2 PFC perfusion using fNIRS

Treatment:

Diagnostic Test: Functional near-infrared spectroscopy (fNIRS)