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Frozen-thawed Embryo Transfer in a Natural Cycle: hCG Triggering Versus LH Home Test

T

Tampere University Hospital

Status and phase

Terminated
Phase 4

Conditions

Infertility

Treatments

Other: Home ovulation test
Drug: Human chorionic gonadotropin

Study type

Interventional

Funder types

Other

Identifiers

NCT03115320
R16172M
2016-003959-29 (EudraCT Number)

Details and patient eligibility

About

The primary aim of this study is to find out if ovulation triggered with hCG provides any additional benefit in comparison to spontaneous LH surge measured with the LH surge home test when transferring frozen-thawed embryo in a natural cycle.

Full description

The aim of this study is to find out the best method for the ovulation triggering. We study the live birth rates in the both groups.

Enrollment

62 patients

Sex

Female

Ages

18 to 42 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

    • Patient with IVF or ICSI cycle and therefore having frozen-thawed embryos
  • Regular menstruation cycle
  • Patient's willingness to participate in the study

Exclusion criteria

    • Irregular menstrual cycle demanding preparing endometrium with hormones for frozen-thawed embryo
  • No frozen embryos after IVF cycle
  • Allergy to Pregnyl® or some of its ingredients in the medication or other contraindications due to Pregnyl®

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

62 participants in 2 patient groups

Pregnyl (Human chorionic gonadotropin)
Experimental group
Description:
In this group, patients have natural cycle in frozen-thawed embryo transfer and the ovulation is confirmed by administration of hCG (Pregnyl® 5000 IU). The day of transferring embryo is depending on the day of administration of hCG and the age of the embryo. The day zero day is defined by ovulation triggered by hCG.
Treatment:
Drug: Human chorionic gonadotropin
Home ovulation test
Other group
Description:
The patients randomized to the LH surge group perform the ovulation home test daily from the urine. Thus, the ovulation in this group is corfimed by the urine test. The day of transferring embryo is depending on the positive ovulation test and the age of the embryo. The day zero day is defined by positive ovulation test.
Treatment:
Other: Home ovulation test

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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