Fructose Extra-splanchnic Metabolism and Its Effects on Systemic Flux of Substrates (FruPP)

University of Lausanne (UNIL)

Status: Completed

Conditions: Test Meal

Treatments: Other: Test meal

Study type: Interventional

Funder types: Other

Identifiers

NCT03195062

2016-01828

Details and patient eligibility

About

In parallel to the dramatic rise in metabolic diseases and diabetes observed over the past fifty years, the generalization of added sugar in processed food led to a marked increase in fructose consumption in almost all countries, and epidemiological studies demonstrated that the consumption of sugar-sweetened beverage (containing at least 50% of fructose) is associated with the development of diabetes, hepatic steatosis, dyslipidemia and obesity.

The objective of the study is to measure the amount of fructose that escape first-pass hepatic extraction after oral ingestion (fructose+glucose), and gain insights into its metabolic fates with the use of tracers.

Enrollment: 9 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Aged from 18 to 40 years
• Body Mass Index of 18.5 to 25 kg/m²
• Sex male of female

Exclusion criteria

• Fructose intolerance
• Antidiabetic and hypolipemic drugs
• Alcohol consumption >10g/day
• Severe eating disorders
• Severe psychological problems
• Vegetarian diet or other specific diet
• Consumption of illicit substances
• Pregnancy
• Weight gain or weight loss > 3 kg in the last 3 months

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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9 participants in 1 patient group

Test meal

Experimental group

Description:

The subjects will receive a liquid test meal containing glucose and fructose with 13C fructose.

Treatment:

Other: Test meal