Fructose-induced Intestinal de Novo Lipogenesis (FIDNL)

U

University of Lausanne (UNIL)

Status

Completed

Conditions

Obesity

Treatments

Other: fat+protein meal
Other: Fat+protein+13C fructose+glucose meal
Other: Fat + protein + 13C fructose meal
Other: 13C Fat + whey protein + glucose+ glucose meal
Other: 13C Fat + whey protein

Study type

Observational

Funder types

Other

Identifiers

NCT01792089
193/11

Details and patient eligibility

About

8 healthy volunteers, 8 pre-bypass obese subjects, 8 subjects between 12-18 months post-bypass, and 8 subjects matched to the post-bypass patients will be studied in two sub-studies Sub-study 1) after ingestion of two or three different of the following test-meals: A)cream and whey protein B)cream, whey protein and fructose + 13C6 fructose C)test meal with cream, whey protein, fructose and glucose + 13C6 fructose Their intestinal de novo lipogenesis will be estimated by measuring 13C-palmitate on triglyceride-rich lipoprotein particles associated with apoB48 in blood Sub-study 2) after ingestion of two or three different of the following test-meals: A)cream labelled with 13C6 palmitic acid and whey protein B))cream labelled with 13C6 palmitic acid, whey protein, fructose and glucose Their intestinal de novo lipogenesis will be estimated by measuring 13C-palmitate on triglyceride-rich lipoprotein particles associated with apoB48 in blood in sub-study 1 Their exogenous lipid absorption kinetics will be assessed by measuring 13C palmitate on triglyceride-rich lipoprotein particles associated with apoB48 in sub-study 2

Enrollment

24 patients

Sex

All

Ages

25 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • age 18-50 years
  • sex male or female
  • less than 2 kg body weight change over the past 3 months subjects

Exclusion criteria

  • antidiabetic and hypolipemic drugs
  • alcohol consumption >20g/day
  • severe eating disorders
  • severe psychological problems
  • vegetarian diet or other specific diet
  • consumption of illicit substances
  • pregnancy
  • weight gain or weight loss > 1 kg in the last 3 months

Trial design

24 participants in 3 patient groups

non-obese healthy subjects
Description:
subjects with BMI<25 and no known disease
Treatment:
Other: 13C Fat + whey protein
Other: 13C Fat + whey protein + glucose+ glucose meal
Other: Fat + protein + 13C fructose meal
Other: Fat+protein+13C fructose+glucose meal
Other: fat+protein meal
post-gastric bypass
Description:
post-obese subjects 12-48 months after Roux-en-Y gastric bypass
Treatment:
Other: 13C Fat + whey protein + glucose+ glucose meal
Other: Fat + protein + 13C fructose meal
Other: fat+protein meal
matched control subjects
Description:
Nonobese, healthy subjects of similar age, weight, and gender ratio, than post-bypass subjects
Treatment:
Other: 13C Fat + whey protein + glucose+ glucose meal
Other: Fat + protein + 13C fructose meal
Other: fat+protein meal

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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