Fuel Selection During Eccentric Cycling With Glucose Ingestion

Université de Montréal

Status: Completed

Conditions: Damage Muscle; Nutrition; Exercise

Treatments: Behavioral: Measure of maximal voluntary contraction force production; Procedure: Indirect respiratory calorimetry; Dietary Supplement: Solution ingestion; Procedure: Blood sampling; Diagnostic Test: Measure of perceived exertion, pain perception and affective response; Diagnostic Test: Measure of muscle electrical activity (EMG); Procedure: Expired gas sampling; Behavioral: Constant load arm cranking; Procedure: Measure of sweat and urine production; Diagnostic Test: Measure of central and cutaneous temperatures

Study type: Interventional

Funder types: Other

Identifiers

NCT03995693

eccentric-exogenous

Details and patient eligibility

About

This study compares fuel selection during eccentric and concentric cycling, with (placebo) or without glucose ingestion during exercise. After a 2-week familiarization and habituation with the ergometers, subjects will complete four experimental conditions in a randomized order: concentric with placebo, eccentric with placebo, concentric with glucose, eccentric with glucose.

Full description

Cycling on a cycle ergometer typically requires repeated concentric muscle contractions to push on the pedals and produce mechanical work. An eccentric cycling ergometer has a motor that rotates the cranks with a predetermined torque, the cyclist needs to resist to the movement of the cranks. This leads to eccentric muscle contractions, the work is thus produced while the muscle is lengthening (negative work). This mode of exercise is known to produce a lower oxygen consumption (energy cost) for the same mechanical power output and also leads to muscle damage which can interfere with fuel selection.

Enrollment: 75 patients

Sex: Male

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Low alcohol consumption (<3 drinks/week)
• Non-smokers
• Not regularly taking medication for a known pathology
• Regularly practices endurance sports (cycling, running, etc.)

Exclusion criteria

• Intolerant to glucose (according to WHO standards)
• Musculoskeletal injury or illness affecting exercise performance
• Failure to respect protocol guidelines (diet, exercise prior to experimentation, etc.)

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Sequential Assignment

Masking: Single Blind

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75 participants in 4 patient groups

Concentric cycling with placebo ingestion

Experimental group

Description:

Participants will complete 45 minutes of arm cranking at an intensity corresponding to 30% of the concentric cycling VO2max, followed by 35 minutes of CONCENTRIC cycling on a recumbent ergometer at the same VO2. A PLACEBO solution (water with a non-caloric sweetener) will be ingested 30 min prior to starting exercise and every 15 min thereafter, until the exercise is completed. Indirect respiratory calorimetry, expired gas sampling, blood sampling will occur will be performed 4 minutes before each ingestion.

Treatment:

Dietary Supplement: Solution ingestion

Procedure: Expired gas sampling

Procedure: Blood sampling

Diagnostic Test: Measure of perceived exertion, pain perception and affective response

Behavioral: Constant load arm cranking

Behavioral: Measure of maximal voluntary contraction force production

Procedure: Measure of sweat and urine production

Diagnostic Test: Measure of central and cutaneous temperatures

Diagnostic Test: Measure of muscle electrical activity (EMG)

Procedure: Indirect respiratory calorimetry

Concentric cycling with glucose ingestion

Experimental group

Description:

Participants will complete 45 minutes of arm cranking at an intensity corresponding to 30% of the concentric cycling VO2max, followed by 35 minutes of concentric cycling on a recumbent ergometer at the same VO2. A GLUCOSE solution (glucose with a trace amount of 13C) will be ingested 30 min prior to starting exercise and every 15 min thereafter, until the exercise is completed. Indirect respiratory calorimetry, expired gas sampling, blood sampling will occur will be performed 4 minutes before each ingestion.

Treatment:

Dietary Supplement: Solution ingestion

Procedure: Expired gas sampling

Procedure: Blood sampling

Diagnostic Test: Measure of perceived exertion, pain perception and affective response

Behavioral: Constant load arm cranking

Behavioral: Measure of maximal voluntary contraction force production

Procedure: Measure of sweat and urine production

Diagnostic Test: Measure of central and cutaneous temperatures

Diagnostic Test: Measure of muscle electrical activity (EMG)

Procedure: Indirect respiratory calorimetry

Eccentric cycling with placebo ingestion

Experimental group

Description:

Participants will complete 45 minutes of arm cranking at an intensity corresponding to 30% of the concentric cycling VO2max, followed by 35 minutes of ECCENTRIC cycling on a recumbent ergometer at the same VO2. A PLACEBO solution (water with a non-caloric sweetener) will be ingested 30 min prior to starting exercise and every 15 min thereafter, until the exercise is completed. Indirect respiratory calorimetry, expired gas sampling, blood sampling will occur will be performed 4 minutes before each ingestion.

Treatment:

Dietary Supplement: Solution ingestion

Procedure: Expired gas sampling

Procedure: Blood sampling

Diagnostic Test: Measure of perceived exertion, pain perception and affective response

Behavioral: Constant load arm cranking

Behavioral: Measure of maximal voluntary contraction force production

Procedure: Measure of sweat and urine production

Diagnostic Test: Measure of central and cutaneous temperatures

Diagnostic Test: Measure of muscle electrical activity (EMG)

Procedure: Indirect respiratory calorimetry

Eccentric cycling with glucose ingestion

Experimental group

Description:

Participants will complete 45 minutes of arm cranking at an intensity corresponding to 30% of the concentric cycling VO2max, followed by 35 minutes of ECCENTRIC cycling on a recumbent ergometer at the same VO2. A GLUCOSE solution (glucose with a trace amount of 13C) will be ingested 30 min prior to starting exercise and every 15 min thereafter, until the exercise is completed. Indirect respiratory calorimetry, expired gas sampling, blood sampling will occur will be performed 4 minutes before each ingestion.

Treatment:

Dietary Supplement: Solution ingestion

Procedure: Expired gas sampling

Procedure: Blood sampling

Diagnostic Test: Measure of perceived exertion, pain perception and affective response

Behavioral: Constant load arm cranking

Behavioral: Measure of maximal voluntary contraction force production

Procedure: Measure of sweat and urine production

Diagnostic Test: Measure of central and cutaneous temperatures

Diagnostic Test: Measure of muscle electrical activity (EMG)

Procedure: Indirect respiratory calorimetry