Full Assessment of Clinical Transfusion Support (FACTS)

Cincinnati Children's Hospital Medical Center

Status: Completed

Conditions: Blood Transfusion; Malaria Parasitaemia; Sickle Cell Anemia

Study type: Observational

Funder types: Other

Identifiers

NCT07094646

FACTS

Details and patient eligibility

About

This study looks at why some children develop very severe anemia that leads to a blood transfusion. It also checks for diseases in the blood they receive. Researchers are using small samples of dried blood (called dried blood spots) from both the children and the donated blood to find out what might be causing the anemia.

Full description

This study includes children at Jinja Regional Referral Hospital (Jinja, Uganda) who need a blood transfusion, whether they are in the clinic, emergency room, or children's ward. After doctors finish the usual blood tests, a small sample of leftover blood will be saved on a special card (called a dried blood spot). The same will be done for all blood transfused during the study. These samples will be frozen and later sent to Cincinnati Children's Hospital for testing.

Enrollment: 250 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Children receiving a blood transfusion in Eastern Uganda at Jinja Regional Referral Hospital.

Exclusion criteria

• If receiving a blood transfusion, refusal or inability to sign an informed consent.

Trial design

250 participants in 4 patient groups

Wet Season - Transfusion

Description:

Those receiving a blood transfusion during the Eastern Uganda wet season.

Dry Season - Transfusion

Description:

Those receiving a blood transfusion during the Eastern Uganda dry season.

Wet Season - Donated

Description:

Transfusion units donated during the Eastern Uganda wet season.

Dry Season - Donated

Description:

Transfusion units donated during the Eastern Uganda dry season.