Function and Morphological Characteristics of Meibomian Gland in Patients With Renal Anemia

Zhongnan Hospital

Status: Enrolling

Conditions: MGD-Meibomian Gland Dysfunction; Dry Eye

Treatments: Diagnostic Test: Dry eye examination

Study type: Interventional

Funder types: Other

Identifiers

NCT06287879

20231121

Details and patient eligibility

About

Renal anemia refers to anemia in which the absolute or relative production of erythropoietin (EPO) is insufficient due to various kidney diseases, and uremic toxins affect erythropoietin production and its lifespan. Common treatment drugs for renal anemia include erythropoietin EPO and Roxadustat (FG-4592).

Medical history information was collected from patients with renal anemia who visited the ophthalmology department with dry eye symptoms.

This study will help to determine the function and morphological characteristics of meibomian gland in patients with renal anemia

Full description

1. Collect medical records of patients with renal anemia who visited the ophthalmology outpatient department of Zhongnan Hospital and hospitalized patients with renal anemia
2. Patients were divided into Rosallistat group, and EPO group according to their drug use history.
3. The dry eye analysis results of all patients were collected, and the lacrimal river height, tear film rupture time and meibomian gland grade were counted. The results of dry eye examination were analyzed statistically.
4. Complete data collection, conduct statistical analysis, and evaluate the analysis results.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• long-term use of Roxadustat or erythropoietin for renal anemia

Exclusion criteria

• contact lens wearer, history of eye surgeries, systemic health conditions affecting ocular health and those who were unable to cooperate with examinations

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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50 participants in 2 patient groups

Roxadustat

Experimental group

Description:

Subjects were treated with Roxadustat for renal anemia

Treatment:

Diagnostic Test: Dry eye examination

EPO

Active Comparator group

Description:

Subjects were treated with EPO for renal anemia

Treatment:

Diagnostic Test: Dry eye examination