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Function-metabolism Coupling in Decision-making Confidence Neural Network of Obsessive-compulsive Disorder

S

Shanghai Mental Health Center

Status

Not yet enrolling

Conditions

Obsessive-Compulsive Disorder

Treatments

Device: Repetitive transcranial magnetic stimulation

Study type

Interventional

Funder types

Other

Identifiers

NCT05563935
2021-51

Details and patient eligibility

About

This study, a case-control study, aims to investigate the function-metabolism coupling in decision-making confidence neural network of obsessive-compulsive disorder.

Full description

OCD shows various abnormalities in cognitive function. Decision-making confidence is a burgeoning research focus on cognitive abnormality of OCD. Gamma-aminobutyric acid (GABA) is a type of inhibitory amino acid. Some studies have indicated that GABA shows metabolic abnormality in OCD.

Repetitive transcranial magnetic stimulation (rTMS) is a safe and noninvasive treatment for OCD. This study intends to explore the differences of the function-metabolism coupling in decision-making confidence neural network between OCD and HC. And investigating the dynamic changes of the function-metabolism coupling after rTMS treatment (6 weeks) for OCD is another goal.

Enrollment

100 estimated patients

Sex

All

Ages

18 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

OCD group:

  1. Age between 18 and 50 years.
  2. Satisfied with the diagnostic criteria for OCD in DSM-V.
  3. Taking medication or unmedication stably for 8 weeks or drug-naive.
  4. YBOCS score ≥16.
  5. Education level was limited to above middle school.
  6. Has sufficient audiovisual skills to complete the necessary examinations for the study.
  7. Right-handed (this criterion is for fMRI subjects only).
  8. Subjects understood the study and signed informed consent.

HC group:

  1. Match with the OCD group on age, gender, education years.
  2. Unsatisfied with the diagnostic criteria for any mental disorder in DSM-V.
  3. No history of taking psychotropic drugs.
  4. No family genetic history of mental disorder.
  5. Has sufficient audiovisual skills to complete the necessary examinations for the study.
  6. Right-handed (this criterion is for fMRI subjects only).
  7. Subjects understood the study and signed informed consent.

Exclusion criteria

OCD group:

  1. Satisfied with the diagnostic criteria for a mental disorder in DSM-V other than OCD.
  2. HAMD-17 score ≥ 17.
  3. IQ < 70.
  4. Obsessive-compulsive symptoms were too severe to participate in the experiment.
  5. Hoarding symptom.
  6. High risk of negative thought and suicide.
  7. Severe central system or physical disease or drug abuse.
  8. Pregnant women or women that getting ready for being pregnant and lactating.
  9. With metal implants in the body, such as pacemakers, intracranial silver clips, metal dentures, arterial stents, arterial clips, joint metal fixation, or other metal implants, etc. (this criterion is for fMRI subjects only)

HC group:

  1. High risk of negative thought and suicide.
  2. HAMD-17 score ≥ 17.
  3. IQ < 70.
  4. Severe central system or physical disease or drug abuse.
  5. Pregnant women or women that getting ready for being pregnant and lactating.
  6. With metal implants in the body, such as pacemakers, intracranial silver clips, metal dentures, arterial stents, arterial clips, joint metal fixation, or other metal implants, etc. (this criterion is for fMRI subjects only)

Trial design

Primary purpose

Basic Science

Allocation

Non-Randomized

Interventional model

Single Group Assignment

Masking

None (Open label)

100 participants in 2 patient groups

OCD group
Active Comparator group
Description:
OCD patients will receive rTMS treatment for 6 weeks.
Treatment:
Device: Repetitive transcranial magnetic stimulation
HC group
No Intervention group
Description:
Health control will not receive any treatment.

Trial contacts and locations

1

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Central trial contact

Qihui Guo

Data sourced from clinicaltrials.gov

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