Functional Assessment in Critically Ill Patients

Universidade Federal do Rio de Janeiro

Status: Enrolling

Conditions: Intensive Care Unit (ICU) Acquired Weakness (ICU - AW); Intensive Care Unit Acquired Weakness

Study type: Observational

Funder types: Other

Identifiers

NCT07191743

65516422.7.0000.5259

Details and patient eligibility

About

This longitudinal, prospective observational study aims to evaluate functional status in critically ill adult patients in the Intensive Care Unit using the Chelsea Critical Care Physical Assessment Tool (CPAx). The primary objective is to analyze CPAx score variation as a potential predictor of clinical outcomes, including mortality and duration of mechanical ventilation. Functional assessments will be performed at intensive care unit (ICU) admission and discharge to monitor changes in physical function and to predict adverse clinical outcomes.

Full description

This prospective, longitudinal, and observational study will be conducted at the general ICU of Pedro Ernesto University Hospital (HUPE). Demographic and clinical information at admission will be collected, including age, sex, type of airway at ICU admission, cause of ICU admission, comorbidities, and clinical scores such as Sepsis-related Organ Failure Assessment (SOFA), Simplified Acute Physiology Score III (SAPS III), and Charlson Comorbidity Index. During the ICU stay, data on the use of invasive mechanical ventilation, non-invasive ventilation, high-flow nasal cannula (HFNC), renal replacement therapy, extubation, and reintubation will be recorded. The CPAx will be assessed at ICU admission and discharge. Additionally, total hospital and ICU length of stay, as well as days on mechanical ventilation, will be recorded.The study aims to analyze the variation in CPAx scores as a predictor of adverse clinical outcomes, including mortality and duration of mechanical ventilation.

Enrollment: 186 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: All adult patients admitted to the Pedro Ernesto University Hospital (HUPE) General ICU over 18 years of age and with an ICU stay greater than or equal to 48 hours will be included.

Exclusion Criteria:

• Pregnancy
• Inability to record the CPAx score within the first 48 hours of ICU admission or on the day of ICU discharge
• ICU readmission
• Known comorbidities causing generalized weakness, such as neuromuscular or neurological diseases

Trial design

186 participants in 2 patient groups

Survivors

Description:

Adult patients admitted to the general ICU at Pedro Ernesto University Hospital (HUPE) who were discharged from the ICU to the hospital ward.

Non-Survivors

Description:

Adult patients admitted to the general ICU at Pedro Ernesto University Hospital (HUPE) who died during their ICU stay.