Functional Brain Imaging of Medication Treatment Response in Mild Alzheimer's Disease Patients

Duke University

Status and phase

Terminated

Phase 4

Conditions

Alzheimer's Disease

Treatments

Drug: Aricept

Drug: Razadyne ER

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT00369603

GAL-EMR-4026 (Other Identifier)

Pro00011149

Details and patient eligibility

About

The purpose of this study is to determine whether standard medications approved for Alzheimer's disease treatment differ in their action on brain functioning and whether any observed brain activity differences as result of treatment are associated with particular patterns of dementia improvement or reduced decline.

Full description

This study seeks to differentiate task-related and resting brain activity patterns captured via functional magnetic resonance imaging (fMRI) and associated with two common Alzheimer's disease (AD) medications, equivalent in acetylcholinesterase inhibition effect (AChEI) but differing with respect to allosteric nicotinic receptor modulation effect. It is the primary aim of this project to gain a better understanding of the brain mechanisms involved in the attentional and executive skills improvements associated with nicotinic receptor modulation in mild AD patients.

To address this question, this 12-week continuous treatment, double-blind, head-to-head dose-escalation treatment trial seeks to visualize any treatment response unique to allosteric nicotinic receptor modulation and to associate these fMRI data with standard cognitive assessment outcomes. Using in-scanner tasks shown to reliably elicit brain activity in cortical regions important to memory and attention, this treatment trial will examine both resting and task-related BOLD signal characteristics in a well-characterized sample of 36 mild AD patients after periods of low dose and high dose AD dementia treatment with either galantamine hydrobromide (AChEI + nicotinic receptor modulation) or donepezil hydrochloride (AChEI only). Both the low and high dose imaging comparisons between treatment groups will be equivalent for 35% AChEI-effect, which may allow for the isolation of BOLD signal unique to allosteric nicotinic receptor modulation in both brain at rest and task-related brain states.

Enrollment

4 patients

Sex

All

Ages

40 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Must meet diagnosis of mild Alzheimer's disease
Must have a family member or caregiver who is willing to attend all study visits and provide information on your participation in the study
If female, must be post-menopausal
Must be able to swallow tablets

Exclusion criteria

Metal implants or medical devises unsafe for MRI use
Pre-menopausal female
HIstory of recent head injury
Significant major, life-threatening illness or injury (e.g., stroke, AIDS, etc.)
Vascular dementia or any dementia other than Alzheimer's Disease
History of significant alcoholism or drug abuse
History of seizure disorder, developmental delay or major psychiatric illness