Functional Capacity Through HRV in Multimodal Rehabilitation for Adult Surgery (PreANI)

Investigation Group Anesthesia, Resuscitation, And Perioperative Medicine of Aragon

Status: Enrolling

Conditions: Frailty in Adult Surgery

Treatments: Behavioral: Trimodal Prehabilitation; Device: Analgesia Nociception Index (ANI) Monitor

Study type: Observational

Funder types: NETWORK

Identifiers

NCT06436417

PreANI001

Details and patient eligibility

About

This prospective, observational cohort study investigates heart rate variability (HRV) monitoring using the Analgesia Nociception Index (ANI) monitor in adult patients undergoing major surgery within a multimodal rehabilitation program. The objective is to correlate HRV indices with functional capacity, physiological reserve, and frailty during the prehabilitation phase.

Full description

The study evaluates HRV using the ANI monitor to determine adaptation to training load, optimize analgesic and anesthetic dosing, and predict postoperative complications. The HRV indices of Energy (SDNN) and ANI (HFnu) are monitored at two points: the initial pre-anesthesia consultation and one week before surgery. Results will be compared with the 6-minute walk test, MUST nutrition screening scale, and clinical frailty and FRAIL scales.

Enrollment: 490 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients over 18 years of age
• Scheduled for major adult surgery
• Any ASA classification
• Signed informed consent

Exclusion criteria

• Urgent surgery
• Severe cognitive impairment
• Patient refusal to participate
• Pediatric patients
• Cardiac arrhythmia or atrial fibrillation

Trial design

490 participants in 2 patient groups

Control

Description:

Patients who do not undergo prehabilitation.

Treatment:

Device: Analgesia Nociception Index (ANI) Monitor

Prehabilitation

Description:

Patients who undergo trimodal prehabilitation including physical exercise, nutritional supplementation, and psychological support.

Treatment:

Device: Analgesia Nociception Index (ANI) Monitor

Behavioral: Trimodal Prehabilitation