Functional Connectivity Measurement After Severe Traumatic Brain Injury (Connectivite)

Grenoble Alpes University Hospital Center (CHU)

Status: Completed

Conditions: Disorder of Consciousness

Treatments: Procedure: MRI: functional (resting state) and structural (DTI)

Study type: Observational

Funder types: Other

Identifiers

NCT02647996

2014-A01873-44

Details and patient eligibility

About

To compare functional connectivity after severe traumatic brain injury (TBI) between a group of post-comatose TBI with restored consciousness and a group of post-comatose TBI with persistant disorder of consciousness at admission in rehabilitation

Full description

Recovery of consciousness can be impaired in severe traumatic brain injury (TBI). Prognostic factors are sparse and mostly clinical (mainly the initial Glasgow coma scale GCS) (1). Functional magnetic resonance imaging (fMRI) could allow a better understanding of functional recovery. Graph method has been applied to fMRI signal analysis in disorder of consciousness (DOC) due to post-anoxic encephalopathy. Comatose state was characterized by dramatic change in local connectivity (hub location) without significant change in global connectivity (2). The present study aims at describing functional connectivity in DOC following severe TBI. We will record resting state fMRI in TBI patients in two clinical conditions: conscious state versus DOC state.

Enrollment: 34 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• severe TBI
• no general anesthesia since 7 days
• no neuroleptic nor hypnotic drug since 3 days
• medical criteria fulfilled to be discharged from ICU
• medical insurance

Exclusion criteria

• age < 18
• contra indication to MRI
• consent refusal from the family
• neurological trouble before TBI
• patient protected by law

Trial design

34 participants in 2 patient groups

Conscious patients

Description:

group: TBI patients awoken from comatose state with normal level of consciousness. intervention: fMRI (resting state) and structural (DTI)

Treatment:

Procedure: MRI: functional (resting state) and structural (DTI)

DOC patients

Description:

group: TBI patients awoken from comatose state with abnormal level of consciousness intervention: fMRI (resting state) and structural (DTI)

Treatment:

Procedure: MRI: functional (resting state) and structural (DTI)