Functional Correlates of Bipolar Disorders and Effects of the Psychoeducation. an fMRI Study (BIP-ED)

Grenoble Alpes University Hospital Center (CHU)

Status: Completed

Conditions: Conditions Influencing Health Status; Bipolar Disorders

Treatments: Behavioral: psychoeducation

Study type: Interventional

Funder types: Other

Identifiers

NCT01821469

2011-A00425-36 (Other Identifier)

EssaiClinique_"BIP-ED"

Details and patient eligibility

About

This research project follows two main objectives: 1) Assess anatomical and functional cerebral abnormalities in bipolar disorder. 2) Evaluate anatomical and functional changes after the application of a psychoeducational program in these patients. Specifically, this project aims to assess neurophysiological (fMRI - activation and functional connectivity) and neuroanatomical (morphometry and diffusion tensor imaging) specificities related to bipolar disorders and the therapeutic response to the psychoeducation. The results of this thesis project would also contribute to the validation of a pathophysiological model of the bipolar disorder.

Enrollment: 45 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• clinical diagnosis of bipolar disorders
• euthymic (Montgomery and Asberg depression rating scale < 10, Young Mania rating scale < 10)

Exclusion criteria

• other concomitant psychiatric disorders

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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45 participants in 1 patient group

psychoeducation

Experimental group

Description:

psychoeducation (12 weeks)

Treatment:

Behavioral: psychoeducation