Functional Exhaustion of T Cells in COVID19 Patients

A

Assiut University

Status

Unknown

Conditions

T Cell Deficiency

Treatments

Diagnostic Test: Flow cytometry

Study type

Observational

Funder types

Other

Identifiers

NCT04470323
T cells

Details and patient eligibility

About

The primary end-point of our prospective, observational study is to count T cells in patients with laboratory-confirmed COVID-19 and healthy controls. In addition, the expression of T cell exhaustion marker was measured in COVID-19 cases.

Full description

COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed great threat to human health. T cells play a critical role in antiviral immunity but their numbers and functional state in COVID-19 patients remain largely unclear. The immune response against viral infections depends on the activation of cytotoxic T cells that can clear infection by killing virus-infected cells, so boosting the numbers and function of T cells in COVID-19 patients is critical for successful recovery. However, the factors which might cause the reduction in count, and the activation status of T cells in COVID-19 patients, remain uninvestigated. Thus demonstration of T cell exhaustion during COVID-19 infection suggest that more urgent, early intervention may be required in patients with low T lymphocyte counts.

Enrollment

100 estimated patients

Sex

All

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Diagnosis of Covid-19 test positive; hospitalized subjects; both sexes; given informed consent.

Exclusion criteria

no exclusion criteriae

Trial design

100 participants in 2 patient groups

COVID19 patients
Description:
Patients admitted to Assiut university Hospitals diagnosed as COVID19 positive patients by PCR.
Treatment:
Diagnostic Test: Flow cytometry
healthy volunteer
Description:
as negative control for each sample
Treatment:
Diagnostic Test: Flow cytometry

Trial contacts and locations

1

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Central trial contact

Hebatallah Hassan, Lecturer

Data sourced from clinicaltrials.gov

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