Functional Imaging in HNC Undergoing Chemoradiation

Royal Marsden NHS Foundation Trust

Status: Unknown

Conditions: Head and Neck Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT00837980

CCR3123

Details and patient eligibility

About

The purpose of the study is to generate a library of functional imaging and anatomical imaging for patients with head and neck cancers for evaluation of new radiotherapy strategies and planning techniques including IMRT. Secondary aims would be to observe the changes in the cancers as the treatment progresses as well as to define the biologically most active part of the tumor (biological target volume) which could be given more intensive treatment. Tumor volumes seen on different imaging modalities will be compared with a hope of finding an optimal imaging methodology for accurate visualization of the head and neck cancers

Full description

Adult patients who have a head and neck cancer and are planned to receive chemotherapy and radiotherapy will be invited to participate in the study. Patients who are not in very good health, have diabetes or kidney failure will not be considered for the study. Also patients who can not undergo MRI scan or are allergic to contrast injection given prior to the scan or have had any other form of cancer (except skin cancer) will also be excluded from the study.

Enrollment: 10 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with histologically proven head and neck cancer, planed for chemotherapy and radiotherapy
• age more than 18 years
• patient willing to participate and has signed a consent form
• patients in good physical status (WHO performance status 0-2)

Exclusion criteria

• patients in poor health (WHO performance status >2)
• patients with any other cancer apart from skin cancer
• patients with contraindications to MRI scan and IV contrast
• diabetic patients
• patients with renal failure