Functional Imaging of Social Cognition in Premanifest Huntington's Disease (FISCIP)

U

Universitaire Ziekenhuizen KU Leuven

Status

Unknown

Conditions

Huntington's Disease

Treatments

Other: functional Imaging

Study type

Interventional

Funder types

Other

Identifiers

NCT02551705
S58457

Details and patient eligibility

About

Huntington's disease (HD) is a genetic progressive fatal neurodegenerative disorder. In the western world it affects 5-10 persons per 100000. The main brain changes include the loss of brain cells in subcortical structures. The symptoms of HD include involuntary movements, cognitive deterioration and behavioural disturbances. It has been shown that changes in emotion comprehension occur before the onset of the motor symptoms (preHD). This deficit in perception of emotions has been primarily investigated by means of facial expressions. However, emotions can also be expressed through body language. Here, the investigators propose to investigate whether the emotion comprehension deficit in preHD also includes body language comprehension.

Full description

The investigators will perform a detailed evaluation of body language comprehension abilities in persons that carry the genetic mutation causing HD, but who do not show any movement symptoms yet. In addition, the associated changes in brain structure and function will be studied. The aim is to perform the study with the same group of participants who participated in a recent study carried on by this research group, in which the functional brain changes associated with increased irritability were investigated. This will allow to relate emotion experience with emotion perception. The results of the study may provide a target to further develop therapeutic interventions and aid caregivers of preHD subjects.

Enrollment

40 estimated patients

Sex

All

Ages

18 to 90 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Huntington's disease positive genotype and non-carrier siblings

Exclusion criteria

  • visible chorea
  • MRI contra-indications
  • major neurological/psychiatric comorbidity

Trial design

Primary purpose

Basic Science

Allocation

Non-Randomized

Interventional model

Crossover Assignment

Masking

Single Blind

40 participants in 2 patient groups

functional Imaging mutation carrier
Experimental group
Description:
Premanifest mutation carrier, behavioral and neural emotional memory processing
Treatment:
Other: functional Imaging
functional Imaging non-carrier
Active Comparator group
Description:
non-carrier family member, behavioral and neural emotional memory processing
Treatment:
Other: functional Imaging

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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