Functional Lung Imaging With DECT and 4DCT

Abramson Cancer Center at Penn Medicine

Status

Completed

Conditions

Non Small Cell Lung Cancer

Treatments

Procedure: contrast enhanced 4DCT

Study type

Observational

Funder types

Other

Identifiers

NCT04702607

UPCC 18520

Details and patient eligibility

About

The basic premise of this pilot study is to enroll 40 patients over 3 years who have Stage II, III, or IV non-small cell lung cancer and are planned for definitive treatment with concurrent chemoradiation where a contrast enhanced 4DCT is planned.

Enrollment

40 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients have histologic diagnosis of non-small cell lung cancer
Patients have AJCC stage II, III or IV disease were the plan is to receive definitive concurrent chemoradiation to 60 Gy or higher
Age > 18 years of age
Patients are able to provide informed consent
No additional lung radiation is planned until after the 2nd CT on this study (i.e. patient does not have a solitary pulmonary nodule or second primary that the plan is to undergo SBRT)
Patient must have adequate kidney function to receive IV contrast (following institutional policy supplied by radiology). The cutoff level for serum creatinine is 1.6 mg/dL
Negative urine pregnancy test before every CT scan

Exclusion criteria