Functional Magnetic Resonance Imaging (fMRI) Exploration of Neurocognitive Processes Involved in Food Addiction (FA) in Obese Patients: Towards New Phenotypic Markers for an Optimized Care Pathway (AddictO)

Rennes University Hospital

Status and phase: Completed; Phase 3; Phase 2

Conditions: Obesity

Treatments: Device: Indirect calorimetry; Biological: Lipid profile, glucose, HBA1c, metabolomic analysis; Device: fMRI; Behavioral: YFAS questionnaire, Binge Eating Scale, Hospital Anxiety and Depression (HAD) scale, hedonic evaluation test (liking); Device: Bioimpedance

Study type: Interventional

Funder types: Other

Identifiers

NCT03454711

2017-A01269-44 (Other Identifier)

35RC17_8949_AddictO

Details and patient eligibility

About

Identification of the cerebral fMRI phenotype of obese patients with FA in cognitive task context based on food choice making

Full description

Obesity is a worldwide epidemic associated with many complications. The treatment of obesity is a failure if it does not take into account eating disorders. Among them, food addictions seem to be frequent among obese patients. Clinical diagnosis and therapeutic approaches depend on presence of these FA. Moreover, eating disorders are associated with visible brain abnormalities in fMRI but the cerebral fMRI phenotype of FA is not known.

Enrollment: 47 patients

Sex: Female

Ages: 30 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• female
• right-handed
• grade 1 and 2 obesity
• aged between 20 and 50
• no other addictions including smoking
• no contraindications to fMRI
• affiliated to French Social Security
• having given a written informed consent

Exclusion criteria

• abdominal circumference + upper limbs along the body > 200cm
• addiction to alcohol or other psychoactive substances
• daily smoker
• sleep Apnea Syndrome paired
• psychotic psychiatric disorders
• history of bariatric surgery
• medical care in the nutrition unit
• inability to comprehend or complete questionnaires
• pregnant or breastfeeding woman
• persons subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty.

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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47 participants in 2 patient groups

Patient with food addcitions

Experimental group

Description:

Patients (20) will be selected from the Yale Food Addiction Scale (YFAS): a validated screening of FA questionnaire. Three clinical visits will be realized in less than two months

Treatment:

Behavioral: YFAS questionnaire, Binge Eating Scale, Hospital Anxiety and Depression (HAD) scale, hedonic evaluation test (liking)

Device: Bioimpedance

Biological: Lipid profile, glucose, HBA1c, metabolomic analysis

Device: Indirect calorimetry

Device: fMRI

Patients without food addictions

Experimental group

Description:

Patients (20) will be selected from the Yale Food Addiction Scale (YFAS): a validated screening of FA questionnaire. Three clinical visits will be realized in less than two months

Treatment:

Behavioral: YFAS questionnaire, Binge Eating Scale, Hospital Anxiety and Depression (HAD) scale, hedonic evaluation test (liking)

Device: Bioimpedance

Biological: Lipid profile, glucose, HBA1c, metabolomic analysis

Device: Indirect calorimetry

Device: fMRI