Functional Magnetic Resonance Imaging - Synthetic Aperture Magnetometry (fMRI-SAM) and Alzheimer's Disease

University Hospital, Strasbourg, France

Status: Withdrawn

Conditions: Alzheimer's Disease

Treatments: Procedure: fMRI to detect MCI patients who will convert to Alzheimer's disease

Study type: Interventional

Funder types: Other

Identifiers

NCT00412048

3659

Details and patient eligibility

About

The aim of the protocol is to study the resting brain activation profile of 3 groups of people, using a new fMRI procedure, called fMRI-SAM. fMRI-SAM will be applied to 25 Alzheimer's disease (AD) patients, 25 patients suffering from amnestic - mild cognitive impairment (MCI) - a clinical picture which may be a prodromal form of AD - and 60 healthy controls. The first analysis of the data will search differences of brain activation profiles between the 3 groups. In the second step, the investigators will study the predictive value of fMRI-SAM to detect MCI patients who will later convert to AD.

Sex: All

Ages: 55 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Alzheimer's disease of mild to moderate severity (25 patients)
• Amnestic MCI patients (25 patients)
• 55-75 year-old patients

Exclusion criteria

• Any other cause of dementia for AD patients
• Any stroke
• Any disease with a negative vital prognosis

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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0 participants in 3 patient groups

ALZHEIMER DISEASE

Other group

Treatment:

Procedure: fMRI to detect MCI patients who will convert to Alzheimer's disease

MOLD COGNITIVE IMPAIRMENT

Other group

Treatment:

Procedure: fMRI to detect MCI patients who will convert to Alzheimer's disease

CONTROLS

Other group

Treatment:

Procedure: fMRI to detect MCI patients who will convert to Alzheimer's disease