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The investigators hypothesize that a functional computational model that simulates the mechanical and aerodynamic behavior of the upper airway in children with Pierre Robin Sequence (PRS) and laryngeal lesions (e.g. subglottic stenosis or SGS) can be used as an effective diagnostic and treatment planning tool.
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Inclusion criteria
Micrognathia, Suspected or Diagnosis of PRS, defined (Gorlin) as:
micrognathia (mandibular hypoplasia), cleft palate and airway obstruction, and/or
Diagnosis of SGS defined (Bluestone) as:
Informed consent by parent or legal guardian
Age < 18 years at enrollment
Scheduled for clinically indicated endoscopic upper airway evaluation
Ability to comply with study visits and study procedures as judged by the site investigator
Inclusion criterion also included for Specific Aim 2 (Longitudinal):
Subjects must be scheduled for an operative procedure to correct or bypass upper airway obstruction (i.e. mandibular distraction, endoscopic airway surgery, laryngotracheoplasty, cricotracheal resection, or tracheostomy) OR recently (within past 4 weeks) diagnosed as having an anomaly not currently requiring surgical management.
Exclusion criteria
Control data will be collected from clinically indicated neck or maxillofacial CT imaging data that include the entire airway with no noted airway obstructions or airway abnormalities.
39 participants in 3 patient groups
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Data sourced from clinicaltrials.gov
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