Functional MRI and MRA in Migraine With Aura

Glostrup University Hospital, Copenhagen

Status: Unknown

Conditions: Migraine With Aura

Study type: Observational

Funder types: Other

Identifiers

NCT01388894

MA-01

Details and patient eligibility

About

Patients who report that exposure to bright light or strenuous physical activity will induce migraine aura will be provoked using one or both of these methods. Followingly the patients will be examined by functional MRI. Íf the patients develop migraine headache, MR angiography will be performed as well. The primary study hypothesis is that the functional MRI signal will show features similar to those of the electrophysiological phenomenon of cortical spreading depression.

Enrollment: 80 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosed with migraine with aura as defined by The International Classification of Headache Disorders 2
• Age between 18 and 80 years both inclusive
• Reports that bright light or strenuous physical activity may trigger migraine aura

Exclusion criteria

• Contraindications towards exposure to photostimulation or strenuous exercise
• Body weight above 130 kg
• Pregnant or lactating females
• Contraindications towards MRI scanning
• History or clinical signs of: cardiovascular disease, psychiatric disease, substance abuse or any symptom or disease considered relevant by the examining physician.