Functional MRI During Resting State in Patients with Eating Disorders

Meyer Children's Hospital IRCCS

Status: Enrolling

Conditions: Bulimia Nervosa; Anorexia Nervosa

Treatments: Diagnostic Test: structural and functional MRI

Study type: Observational

Funder types: Other

Identifiers

NCT06874348

RS-FMRI-ED

Details and patient eligibility

About

The goal of this observational study is to learn if clinical and neurophysiological characteristics dynamics may follow similar trends in a longitudinal characterization of patients with a diagnosis of an eating disorder.

The primary hypothesis is that the reversal of Functional Magnetic Resonance Imaging (fMRI) baseline alternations is positively associated with symptomatic amelioration.

The secondary hypothesis is that the degree of (f)MRI baseline alternations is positively associated with symptoms.

Participants will be asked to complete psychometric questionnaires, perform a fMRI and be recalled at 12 months for a follow-up.

Enrollment: 50 estimated patients

Sex: Female

Ages: 12 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Female sex
• Age between 12 and 40 years old
• Current diagnosis of Anorexia Nervosa or Bulimia Nervosa according to DSM-5-TR.

Exclusion criteria

• Previous or current diagnosis of schizophrenia or bipolar disorder,
• Acute psychosis
• Substance abuse
• Severe medical comorbidities (hypercapnia, severe hypertension, cardiac arrhythmia, organ failure)
• incapacity to grant written or verbal consent

Trial design

50 participants in 4 patient groups

Anorexia Nervosa - minors

Treatment:

Diagnostic Test: structural and functional MRI

Bulimia Nervosa - minors

Treatment:

Diagnostic Test: structural and functional MRI

Anorexia Nervosa - adults

Treatment:

Diagnostic Test: structural and functional MRI

Bulimia Nervosa - adults

Treatment:

Diagnostic Test: structural and functional MRI