Functional MRI for Monitoring Progression and Assessing Trends in ILD (IMPACT-ILD)

University Hospital Heidelberg

Status

Enrolling

Conditions

Interstitial Lung Diseases (ILD)

Treatments

Diagnostic Test: Lung MRI Protocol with Functional and Contrast-Enhanced Sequences

Study type

Interventional

Funder types

Other

Identifiers

NCT07300696

S-296/2024

Details and patient eligibility

About

The main objective of this study is to investigate the utility of functional MRI to differentiate, characterize, and monitor subgroups of ILD. This can be broken down into three specific objectives:

Determine if ILD features observed on high-resolution computed tomography (HRCT), such as ground glass opacities (GGO), are functionally different.

Analyse MRI metrics within each subgroup to determine whether these metrics distinguish different ILDs.

Assess MRI metrics longitudinally to see if these parameters change with disease progression, stability, or reversibility.

Enrollment

200 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Clinical indication for a routine HRCT because of either newly diagnosed idiopathic pulmonary fibrosis (IPF) or hypersensitivity pneumonitis (HP) or idiopathic non-specific interstitial pneumonia (iNSIP), suspected diagnosis, or follow-up
Capacity to consent
Ability to participate fully in the study (defined by the ability to lie still for the duration of imaging)

Exclusion criteria

Pregnancy and breast feeding
Persons under the age of 18 and persons not able to give informed consent
Any medical conditions that could hinder the ability to adhere to the protocol
Any MRI contraindication, including previous allergic reactions to Gd-based MRI contrast material and renal dysfunction (eGFR < 30 ml min/1,73 m2)