Functional Muscle-Bone Incongruity Index (FKUI): A Prospective Observational Study

Kanuni Sultan Suleyman Training and Research Hospital

Status: Enrolling

Conditions: Osteopenia; Osteoporosis; Musculoskeletal Health; Sarcopenia

Study type: Observational

Funder types: Other

Identifiers

NCT07677033

KSS-TRH-FKUI-2026 (Other Identifier)

FKUI

Details and patient eligibility

About

The Functional Muscle-Bone Incongruity Index (FKUI) is a novel approach developed to evaluate the relationship between muscle function and bone health. This prospective observational study aims to investigate the clinical applicability of FKUI, which combines handgrip strength, total hip bone mineral density (BMD), and lumbar-hip BMD discordance. Approximately 200 adult participants undergoing routine DXA assessment will be enrolled. The study will examine whether the combined evaluation of muscle function and bone health parameters provides a more comprehensive assessment of musculoskeletal status than individual measures alone.

Full description

This is a prospective, observational, single-center study evaluating adults undergoing routine DXA assessment in a Physical Medicine and Rehabilitation outpatient clinic. The study will investigate the clinical applicability of the Functional Muscle-Bone Incongruity Index (FKUI), a composite approach based on handgrip strength, total hip bone mineral density, and lumbar-hip bone mineral density discordance. No treatment or interventional procedure will be administered as part of the study. Handgrip strength will be measured using a calibrated hand dynamometer, and DXA-derived bone mineral density values will be recorded from routine clinical assessments. The study aims to determine whether the combined evaluation of muscle function and bone health parameters may provide a more comprehensive assessment of musculoskeletal status.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18 years or older
• Attendance at the Physical Medicine and Rehabilitation outpatient clinic
• Scheduled to undergo routine bone mineral density assessment by DXA as part of clinical evaluation
• Ability to perform handgrip strength testing
• Availability of lumbar spine and total hip bone mineral density measurements suitable for analysis
• Ability and willingness to provide written informed consent

Exclusion criteria

Exclusion Criteria:

• Age younger than 18 years
• Secondary causes of osteoporosis (e.g., hyperparathyroidism, Cushing syndrome, malignancy, or other conditions affecting bone metabolism)
• History of metabolic bone disease
• Major trauma or fracture within the previous 6 months
• Upper extremity disorders that may significantly affect handgrip strength measurement (e.g., severe osteoarthritis, neurological disorders, major deformities)
• DXA measurements that are technically inadequate or unsuitable for analysis
• Refusal or inability to provide written informed consent

Trial design

200 participants in 1 patient group

Adults Undergoing Bone Mineral Density Evaluation

Description:

Adult patients attending the Physical Medicine and Rehabilitation outpatient clinic and undergoing routine DXA assessment as part of clinical evaluation. Participants will undergo handgrip strength measurement and assessment of bone mineral density parameters. The Functional Muscle-Bone Incongruity Index (FKUI) will be evaluated using handgrip strength, total hip bone mineral density, and lumbar-hip bone mineral density discordance. No treatment or interventional procedure will be administered.