Functional Neural Connectivity at Rest as a Diagnostic Tool for Intolerance to Heat (fMRI)

Sheba Medical Center

Status: Unknown

Conditions: Functional Neural Connectivity

Treatments: Device: MRI scans

Study type: Observational

Funder types: Other

Identifiers

NCT02498158

2380-15-SMC

Details and patient eligibility

About

Functional neural connectivity at rest of 3 groups (heat tolerant, heat intolerant and healthy subjects) will be assessed using the anatomical and functional MRI scans and compared.

Full description

20 healthy subjects that had already underwent Heat Tolerance Test (HTT) at the Heller Institute of Medical Research (Sheba Medical Center) will be recruited and divided into 2 groups: heat tolerant and heat intolerant (according to the HTT results). They will be asked to arrive to one experimental day at the imaging department in Sheba Medical Center and undergo anatomical and functional MRI scans.

Third group will consist of 10 existing brain scans (separated from personal details) of healthy males, at the same age range and who had never gone through heat injury.

Data will be analysed by fMRI expert in order to compare the functional neural connectivity at rest between the three groups.

Enrollment: 20 estimated patients

Sex: Male

Ages: 18 to 25 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• generally healthy subjects
• underwent heat injury in the past two months
• underwent Heat Tolerance Test at the Heller Institute of Medical research

Exclusion criteria

• drug or alcohol use
• history of neurological disorders, mental retardation or head injury
• history or diagnosis of psychiatric disorders
• claustrophobia

Trial design

20 participants in 1 patient group

experimental protocol

Description:

Functional neural connectivity at rest of 3 groups (heat tolerant, heat intolerant and healthy subjects) will be assessed using the anatomical and functional MRI scans and compared.

Treatment:

Device: MRI scans