Functional Neuroimage in Assessment of Post-stroke Aphasia

vghtpe user

Status: Unknown

Conditions: Stroke; Aphasia

Treatments: Device: rTMS

Study type: Interventional

Funder types: Other

Identifiers

NCT02120508

201207007AC

Details and patient eligibility

About

The substantial efficacy and the possible mechanism of repetitive transcranial magnetic stimulation (rTMS) improving language recovery remained unclear. It is hypothesized that the rTMS was associated with increased synaptic connection and neural regeneration which can be evaluated via functional neuroimage and neurofiber imaging analysis. The effect of rTMS intervention was monitored by clinical testing and neuroimaging study.

Full description

2-week rTMS modulation has been proved to produce substantial clinical benefit with sham-controlled study. This trial aimed to investigate the possible mechanism and make clinical correlation.

Enrollment: 60 estimated patients

Sex: All

Ages: 25 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aphasic stroke in chronic stage (over 3 months)

Exclusion criteria

• No seizure history, no brain surgery history, no electronic device in brain or chest, no dementia

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

60 participants in 2 patient groups

1 Hz rTMS, real

Experimental group

Description:

1 Hz rTMS over unaffected hemisphere for 15 minutes

Treatment:

Device: rTMS

1Hz rTMS, sham

Sham Comparator group

Description:

1Hz sham rTMS, over unaffected hemisphere for 15 minutes

Treatment:

Device: rTMS