Functional Neuroimaging and Genetic Vulnerability to Suicidal Behavior

University Hospital Center (CHU)

Status: Terminated

Conditions: Suicidal Behavior

Treatments: Device: Magnetic resonance imaging (MRI)

Study type: Interventional

Funder types: Other

Identifiers

NCT02960191

7887

Details and patient eligibility

About

The main objective is to highlight, by functional imaging (MRI) dysfunctional brain regions associated with vulnerability to suicidal behavior.

Enrollment: 95 patients

Sex: Male

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• right-handed
• arm suicidal : Personal history of unipolar depressive disorder or bipolar disorder and having realized in his life at least one suicide attempt
• arm emotional Witnesses : Personal history of unipolar depressive disorder or bipolar disorder and have never done in his life attempted suicide
• arm healthy Witnesses : any current or past personal history of psychiatric disorders of Axis I and have never done in his life attempted suicide

Exclusion criteria

• Cons-indications to the use of MRI
• Existence of a past history of head trauma with loss of consciousness or neurological brain disorder or secondary neurological suffering suicidal gesture.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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95 participants in 3 patient groups

healthy volunteers

Other group

Description:

subject with no current or past personal history of psychiatric disorders and about never having carried out suicide attempt

Treatment:

Device: Magnetic resonance imaging (MRI)

emotional witness

Other group

Description:

subject having had a personal history of unipolar or bipolar depressive disorder and who have never done in his life attempted suicide

Treatment:

Device: Magnetic resonance imaging (MRI)

patient suicide

Other group

Description:

subject having had a personal history of unipolar or bipolar depressive disorder and having realized in his life at least one suicide attempt

Treatment:

Device: Magnetic resonance imaging (MRI)