Functional Residual Capacity (FRC) Guided Alveolar Recruitment Strategy

University of Luebeck

Status and phase: Completed; Phase 4

Conditions: Ventilation; Functional Residual Capacity

Treatments: Procedure: Alveolar recruitment manoeuvre

Study type: Interventional

Funder types: Other

Identifiers

NCT00779090

FRCGARS-1

Details and patient eligibility

About

In ventilated patients open endotracheal suctioning may lead to alveolar derecruitment, which can be monitored by means of functional residual capacity (FRC) measurements. The investigators hypothesized that a recruitment strategy based on FRC measurements would improve oxygenation and regional ventilation after an open endotracheal suctioning manoeuvre.

Full description

In mechanically ventilated patients the functional residual capacity will be measured before (baseline) and after an open endotracheal suctioning manoeuvre. Based on these changes patients will be divided into two groups: Group A with more than 94% of baseline FRC, and Group B with less than 94% of baseline FRC. Both groups will be randomized to receive an alveolar recruitment manoeuvre or no alveolar recruitment manoeuvre, leading to four groups. Oxygenation and regional ventilation with electrical impedance tomography will be studied.

Enrollment: 59 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ventilated after elective cardiac surgery

Exclusion criteria

• hemodynamic instability (eg. intraaortic balloon pump)
• acute lung injury, i.e. PEEP > 10cmH20 or FiO2 > 0.4

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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59 participants in 4 patient groups

Group A_RM

Experimental group

Description:

Patients with FRC after open endotracheal suctioning of more than 94% of baseline randomized to receive an alveolar recruitment manoeuvre.

Treatment:

Procedure: Alveolar recruitment manoeuvre

Group A_NRM

No Intervention group

Description:

Patients with FRC after open endotracheal suctioning of more than 94% of baseline randomized to receive no alveolar recruitment manoeuvre.

Group B_RM

Experimental group

Description:

Patients with FRC after open endotracheal suctioning of less than 94% of baseline randomized to receive an alveolar recruitment manoeuvre.

Treatment:

Procedure: Alveolar recruitment manoeuvre

Group B_NRM

No Intervention group

Description:

Patients with FRC after open endotracheal suctioning of less than 94% of baseline randomized to receive no alveolar recruitment manoeuvre.