Functionality of an 8-Channel Paddle Coil for Use With MRI

Sunnybrook Health Sciences Centre

Status: Completed

Conditions: Prostate in Healthy Males

Treatments: Device: 8-channel paddle coil

Study type: Interventional

Funder types: Other

Identifiers

NCT02190344

019-2014

Details and patient eligibility

About

The objective of this study is to determine the functionality of an eight-channel paddle coil system which is to be used in future MRI studies.

Full description

Prostate cancer is the most common malignancy among men and the second leading cause of cancer death in men. Currently, MRI is the best imaging modality for both detecting prostate cancer and determining the presence of extra-prostatic extension. Multiparametric Magnetic Resonance, combining T2-weighted, diffusion-weighted and dynamic contrast enhanced imaging (DCE-MRI) is recommended as the minimum acceptable standard for prostate MRI examination. However, MPMRI still lacks diagnostic accuracy in the transition zone, where distinguishing cancer from proliferative nodules has proven difficult. DCE-MRI techniques evaluate the time course of signal intensities after administration of a contrast medium and have been used to successfully differentiate benign from malignant tumours, particularly in breast and prostate cancer. Unfortunately, current DCE approaches have high false-positive rates and are limited in distinguishing prostatitis and vascularized BPH nodules from cancer in active surveillance studies. Future studies that employ spectroscopic MR imaging of the prostate after administration of Hyperpolarized (13C) Pyruvate Injection, are expected to provide a robust, non-invasive method to assist in detecting and characterizing prostate cancer. The objective of this study is to determine the functionality of an eight-channel paddle coil system which is to be used in future Hyperpolarized (13C) Pyruvate Injection studies.

Enrollment: 1 patient

Sex: Male

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy male volunteers between 18 and 80 years of age

Exclusion criteria

• Any contra-indication for MR imaging (such as pacemakers, surgical implants, foreign metal objects in the body)

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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1 participants in 1 patient group

Functionality of 8-channel paddle coil system

Experimental group

Treatment:

Device: 8-channel paddle coil