Fungal Vascular Graft Infections, French Multicenter Retrospective Study (FUNGIVAS)

University Hospital of Bordeaux

Status: Not yet enrolling

Conditions: Fungal Infection; Vascular Grafting

Treatments: Other: epidemiology and medical treatment strategies

Study type: Observational

Funder types: Other

Identifiers

NCT07143409

CHUBX 2025/025

Details and patient eligibility

About

Fungal vascular graft and endograft infections (VGEIs) are rare but life-threatening infections. Best therapeutic management is unknown. This study retrospectively gathers fungal VGEIs from 12 university hospital centers in France over a 10 year's period in order to describe their epidemiology, clinical features, therapeutic management and outcomes. Focusing on Candida spp. VGEIs, we aim to determine prognosis factors associated with therapeutic management

Full description

Fungal vascular graft and endograft infections (VGEIs) are rare but life-threatening infections. Candida spp. is the most frequent fungal agent. Main risk factor is prostheto-digestive fistula. Best therapeutic management is unknown. The aim of FUNGIVAS study is to describe epidemiology, clinical features, therapeutic management and outcomes of fungal VGEIs and determine prognosis factors associated with therapeutic management. This study retrospectively gathers fungal VGEIs from 12 university hospital centers in France from January 2013 to January 2023. Patients will be identified from mycology laboratories that have diagnosed the fungal infection on a vascular sample. Demographic, clinical, biological, imaging and outcome data will be collected using a secure and anonymous questionnaire

Enrollment: 300 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged ≥ 18 years old with diagnosis of vascular graft and endograft infections (VGEI) in accordance to MAGIC criteria with diagnosis of proven invasive fungal infection according to EORTC criteria.
• No opposition to re-use data.

Exclusion criteria

• Patient previously treated for fungal VGEI
• Patient with suspected VGEI diagnosis based solely on prosthesis implantation in an infected site
• Poor understanding of French.
• Patient under legal protection.