Furosemide Stress Test Predicting Early Graft Function in Kidney Transplantation (FOSTIK)

King Chulalongkorn Memorial Hospital

Status: Enrolling

Conditions: Kidney Transplant; Complications; Kidney Function; Delayed Graft Function

Treatments: Drug: Furosemide Injection

Study type: Interventional

Funder types: Other

Identifiers

NCT03071536

IRB 317/59

Details and patient eligibility

About

Furosemide is an old drug that has been used frequently in the postoperative period of kidney transplantation, aiming to achieve adequate urine output. There is no previous study that directly evaluate the urine response to standardized dose of furosemide in the postoperative period. The objective is to measure the urine output after standardized dose of furosemide is delivered, as a biomarker to predict the graft function in perioperative period.

Enrollment: 180 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Deceased donor kidney transplantation at KCMH
• informed consent is accepted

Exclusion criteria

• Known allergy to furosemide
• Surgical complication of allograft
• Urgently needed for dialysis (refractory hypervolemia, uremic symptoms, and hyperkalemia)

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

180 participants in 1 patient group

Furosemide

Experimental group

Description:

Single dose of furosemide 1.5 mg/kg intravenously will be given to all participants at 3 hours post-reperfusion of kidney allograft. Urine output will be recorded hourly for 6 hours.

Treatment:

Drug: Furosemide Injection