Fycompa in Catamenial Epilepsy

University of Florida

Status and phase

Terminated

Phase 4

Conditions

Catamenial Epilepsy

Treatments

Drug: Fycompa

Drug: Fycompa with a boost

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT05201703

IRB202102694

Details and patient eligibility

About

The purpose of the proposed investigation is to carry out a pilot study of add-on perampanel (Fycompa) in women with perimenstural (C1) catamenial epilepsy. Perampanel, a noncompetitive AMPA receptor antagonist, is uniquely positioned to decrease progesterone receptor mediated excitotoxicity. This mechanism of action would allow a novel use of perampanel as an effective treatment of C1 catamenial epilepsy.

Enrollment

7 patients

Sex

Female

Ages

18 to 50 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Female
Diagnosis of focal onset seizures (FOS) i. Established by clinical history and an EEG ii. Patients with a normal EEG may be included if they met other diagnostic criteria based on clinical history
Presumably ovulatory women based on menstrual cycles of 21-35 days from beginning of menstrual flow to the beginning of the next menses
≥18-50 years old
≥2 unprovoked seizures per month despite drug trials with ≥1 first-line anti-epileptic drugs (AED)
Seizures must show a C1 catamenial pattern in 2 of 3 documented cycles i. C1 pattern will be defined as a two-fold increase in average daily seizure frequency during the menstrual phase, as compared to the follicular and luteal phases of the ovulation cycle, in 2 of 3 documented cycles. The menstrual phase will be defined as days -3 to +3 of the menstrual cycle (where onset of menstruation is defined as day 1) (Herzog et al, 1997). Of note, in the NIH Progesterone Trial, the level of catameniality was 1.69 based on Herzog et al. (1997) criteria though this trial will use a level of 2 to include women only with high levels of perimenstrual catamenial exacerbation.
Willingness and ability to comply with scheduled visits and study procedures

Exclusion criteria

Progressive neurologic or systemic disorder
Use of systemic hormonal contraception during 3 months prior to enrollment (however, subjects with a progestin-releasing IUD who still have monthly periods may be enrolled)

a. Women on system hormonal contraception will be excluded as these women are not ovulatory
Subject is pregnant or breastfeeding
Active suicidal or homicidal ideation
Comatose individuals.