G-CSF and PRP in Patients With Recurrent Implantation Failure

Riyadh Fertility and Reproductive Health center

Status and phase: Unknown; Phase 2

Conditions: Infertility,Female

Treatments: Drug: Granulocyte colony-stimulating factor and platelet-rich plasma group; Other: Control group

Study type: Interventional

Funder types: Other

Identifiers

NCT04411212

G-CSF and PRP in RIF

Details and patient eligibility

About

The aim of this randomized controlled trial is to determine whether granulocyte colony-stimulating factor and platelet-rich plasma can be used to enhance the IVF-ET outcomes in patients with recurrent implantation failure

Enrollment: 112 estimated patients

Sex: Female

Ages: 1 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with history of three or more unsuccessful IVF-ET cycles with at least 2 good quality embryos transferred

Exclusion criteria

• Endometriosis
• Uterine anomalies
• Asherman syndrome

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

112 participants in 2 patient groups

Granulocyte colony-stimulating factor and platelet-rich plasma

Active Comparator group

Treatment:

Drug: Granulocyte colony-stimulating factor and platelet-rich plasma group

Control group

Other group

Treatment:

Other: Control group