GABA and Beta-cell Regeneration

Ministry of Health and Population, Egypt

Status: Completed

Conditions: Diabetes Mellitus, Type 1

Treatments: Drug: GABA

Study type: Observational

Funder types: Other

Identifiers

NCT04375020

icel

Details and patient eligibility

About

GABA(gamma-Aminobutyric acid) may be used for decreasing anti-gad antibodies and leads beta-cell regeneration.

Full description

100 patients with type I diabetes were in 2 groups, had been monitored in a private clinic, number 50 each group, with 30 females and 20 males after the written consent of all patients.

All the patients Lied between 18-25 years old with 5-10 years of diabetes onset.

The first group was on insulin therapy in the form of toujeo once daily and Novorapid 3 times daily and they received GABA nutritional supplement 750mg per day.

The second group was only on insulin injection in the form of toujeo once daily and Novorapid 3 times daily.

In the first group;the investigator measured fasting c peptide levels before and after 6 months of GABA 750mg daily.Also,the investigator measured anti gad antibodies before and after 6 months of treatment.

In the second group,the investigator measured c peptide levels and anti-gad antibodies at the beginning of the trial and after 6 months.

Enrollment: 100 patients

Sex: All

Ages: 18 to 25 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• type 1 diabetes patients age from 18 to 25 years on basal bolus insulin

Exclusion criteria

thyroid problems liver disease kidney disease

Trial design

100 participants in 2 patient groups

group1 on GABA

Description:

The first group was on insulin therapy in the form of toujeo once daily and Novorapid 3 times daily and they received GABA nutritional supplement 750mg per day.

Treatment:

Drug: GABA

group 2 on just insulin

Description:

The second group was only on insulin injection in the form of toujeo once daily and Novorapid 3 times daily.