Gabapentin and Diclofenac Sodium Comparison for Post-Operative Pain Relief

Muhammad Aamir Latif

Status: Completed

Conditions: Postoperative Pain

Treatments: Drug: Diclofenac Sodium 100 MG; Drug: Gabapentin 600mg

Study type: Interventional

Funder types: Other

Identifiers

NCT07267182

DR-SAIMA-QAMC

Details and patient eligibility

About

Little is known about comparative efficacy of gabapentin and diclofenac sodium in managing post-operative pain. Therefore, this study was planned to compare the efficacy of gabapentin, and diclofenac sodium for post-operative pain relief in patients undergoing major abdominal surgeries.

Full description

Non-steroidal anti-inflammatory drugs, opioid analgesics, and local and regional anesthesia have been used as preventive interventions, but their role in postoperative pain management remains inconclusive. Gabapentin is a relatively new drug for postoperative pain management whose side effects are well tolerated. If the findings of this study produce similar observations, it would add to the already scarce data and help patients undergoing major abdominal surgeries in the local settings in relieving postoperative pain effectively.

Enrollment: 240 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Any gender
• Aged 18-60 years
• Undergoing elective major abdominal surgery under general anesthesia
• With physical status I or II
• Who were able to comprehend and use the Visual Analogue Scale (VAS) for pain assessment

Exclusion criteria

• With a known allergy or contraindication to gabapentin, or diclofenac sodium
• A history of peptic ulcer disease
• A history of gastrointestinal bleeding
• Hepatic or renal dysfunction
• Pregnancy or lactation
• With neurological or psychiatric disorders affecting pain perception
• Received opioids, anticonvulsants, antidepressants, or nonsteroidal anti-inflammatory drugs (NSAIDs) within 24 hours before surgery
• With uncontrolled hypertension, ischemic heart disease, or diabetes mellitus
• Those who experienced intraoperative complications necessitating a change in anesthetic plan or postoperative mechanical ventilation

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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240 participants in 2 patient groups

Gabapentin group

Experimental group

Description:

Patients received a single oral dose of gabapentin 600 mg one hour before surgery.

Treatment:

Drug: Gabapentin 600mg

Diclofenac group

Experimental group

Description:

Patients were given a single oral dose of diclofenac sodium 100 mg one hour before surgery.

Treatment:

Drug: Diclofenac Sodium 100 MG