Gait Analysis in Moderate Hemophiliac Patients (AQM-Hemophile)

Nantes University Hospital (NUH)

Status

Completed

Conditions

Moderate Hemophilia

Arthropathy

Treatments

Other: Gait analysis

Study type

Interventional

Funder types

Other

Identifiers

NCT04024176

RC18_0271

Details and patient eligibility

About

The management of moderate hemophilia is less codified than those of severe patients; because these patients are theoretically less likely to bleed and therefore less likely to develop arthropathies. Nowaways, the question arises as to the appropriateness of this "symptomatic" management for the prevention of the occurrence of hemophilic arthropathies. Indeed, a significant number of moderate hemophiliacs seems to develop severe arthropathies that cause significant disability. However, because of the very small proportion of these patients in the total number of hemophiliacs, data are lacking on the impact of arthropathies on this population. The investigators therefore propose to include moderate hemophiliac patients in the study to carry out an evaluation of gait, using a gait analysis to determine the consequences of arthropathies, even sub-clinical ones, according to the duration of the disease's progression. In an associated way, the analysis of different clinical (joint assessment; quality of life score;...), radiological (radiographic; ultrasound (synovial thickness)), biological (level of associated factors ; other associated marker), in order to provide a complete picture of the articular situation in these patients with moderate haemophilia.

Enrollment

24 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Have moderate Hemophilia A or B.
Have understood the protocol and signed its consent to participate.
Patient able to perform a walking test.
Patient affiliated to a social security system

Exclusion criteria

Pregnant women
Minor
Majors under guardianship or curatorship
Refusal to participate;
Amputee of a lower limb
Need for technical walking assistance (walking sticks, walker,...).
Extensive dermatitis of the lower limbs (need for sensor installation for gait analysis);
Known NYHA (New York Heart Association) grade III or IV heart failure (resting dyspnea);
Unstable angina or myocardial infarction within three months of inclusion
Known severe respiratory disease;
Parkinson's disease, hemiplegia or paraplegia
Patient unable to understand the objectives or instructions of the study
Intercurrent pathology likely to modify walking abilities