Gait and Alzheimer Interaction Tracking (GAIT) Study

University Hospital, Angers

Status

Completed

Conditions

Cerebral Atrophy

Alzheimer Disease

Gait Apraxia

Impaired Cognition

Study type

Observational

Funder types

Other

Identifiers

NCT01315717

2009-A00533-54

Details and patient eligibility

About

The purpose of this study is to examine and to compare gait characteristics under single- and dual-task conditions among healthy subjects together with AD patients at different stages of disease (i.e., pre-dementia, mild and moderate dementia stages).

Full description

Although gait disorders are frequently associated with Alzheimer's disease (AD), few studies have focused on their characterization and mechanism. Exploring the associations of the gait characteristics - more particularly the gait variability - with the cognitive performance of AD patients on one hand, and with the morphological brain abnormalities on the other hand, could be useful to understanding the mechanisms of gait disorders in AD.

The main objective of this study is to examine and to compare gait characteristics under single- and dual-task conditions among healthy subjects together with AD patients at different stages of disease (i.e., pre-dementia, mild and moderate dementia stages).

Enrollment

912 patients

Sex

All

Ages

60+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age ≥ 60 years
Able to walk without walking aid on 15 metres
Score of Mini-Mental Examination (MMSE) > 10
Written informed consent to participate in the study (or trustworthy person)
Being affiliated to a social security regime
Near visual acuity ≥ 2/10
Absence of severe depression (score in the 15-item Geriatric Depression Scale ≤ 10)

Exclusion criteria

Score of Mini-Mental Examination (MMSE) ≤ 10
Subject suffering from pre-existing impellent disturbances
History of cerebrovascular accident or other cerebro-spinal pathology
Poor workmanship of the written or oral French language
Refusal of subject to be informed on possible hanging bare anomaly during study
Use of walking aid
Acute medical or surgical disease in the past 3 months
Refusal to participate (or trustworthy person)
Contra-indication to the achievement of a Magnetic Resonance Imaging
Near visual acuity < 2/10
Presence of severe depression (score in the 15-item Geriatric Depression Scale > 10)