Gait, cOgnitiOn & Decline (GOOD)

University Hospital, Angers

Status: Unknown

Conditions: Healthy; Moderate Dementia; Mild Dementia; Mild Cognitive Impairment

Treatments: Other: gait and cognitive testing

Study type: Observational

Funder types: Other

Identifiers

NCT02350270

2014-17

Details and patient eligibility

About

The main objective of the GOOD initiative was to determine which spatio-temporal gait parameters and/or combination(s) of spatio-temporal gait parameters best differentiate between cognitively healthy individuals (CHI), patients with mild cognitive impairment (MCI) and those with mild and moderate dementia.

Full description

Gait disorders are frequent in individuals with cognitive disorders. However, the profile of spatio-temporal gait parameters in the different cognitive status in aging (from normal cognition to dementia) has been poorly studied. Determining this profile associated with the severity of cognitive disorders may be helpful to understand the complex interplay between gait and cognitive disorders and, thus, may have important implication for the diagnosis process of patients with and without dementia. For instance, defining a motor phenotype of the severity of cognitive disorders by using quantitative gait measurements could be used to improve the prediction and the diagnosis of dementia.

The investigators hypothesized that, compared to CHI, people with MCI and mild dementia could be characterized by specific phenotypes of spatio-temporal gait parameters measured with the GAITRite® system, and that these profiles could be explained by declines in domain-specific cognitive performance.

Enrollment: 2,800 estimated patients

Sex: All

Ages: 60+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Being 60 years old and older
• Ability to answer questions

Exclusion criteria

• Opposition to the use of information collected for research purposes

Trial design

2,800 participants in 3 patient groups

cognitively healthy individuals (CHI)

Description:

CHI were participants without objective cognitive impairment

Treatment:

Other: gait and cognitive testing

mild cognitive impairment (MCI)

Description:

MCI was diagnosed if participants met the following criteria: presence of spontaneous cognitive complaints and objective cognitive impairment

Treatment:

Other: gait and cognitive testing

mild and moderate dementia

Description:

Diagnoses of dementia were assigned according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV TR, 2000; Association, 2000; 22) at consensus diagnostic case conferences

Treatment:

Other: gait and cognitive testing