Gait, Stair Climbing and Postural Stability in Knee Osteoarthritis Patients After Hyaluronic Acid Injection

University of Malaya

Status and phase: Completed; Phase 3

Conditions: Bilateral Knee Osteoarthritis

Treatments: Other: Hyaluronic acid

Study type: Interventional

Funder types: Other

Identifiers

NCT02063373

UM/MOHE/HIR D000010-16001

Details and patient eligibility

About

Treatment: five intro-articular Hyaluronic Acid injection

Assessment has two parts, that are as follow:

1. Postural stability and risk of fall assessment using Biodex stability index and "Timed up and Go" test
2. Gait and stair climbing assessment using Vicon motion capture system synchronized with four force plates.

For knee OA subjects, assessment was done in week one or before injection; and for healthy controls one assessment was performed.

Full description

This study aimed to assess the effect of hyaluronic acid injection on Postural stability, biomechanics of gait and stair climbing in individuals with bilateral knee osteoarthritis (OA).

Participants were individuals with knee OA (control and treatment) and healthy people.

Enrollment: 85 patients

Sex: All

Ages: 50 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Mild and moderate bilateral knee osteoarthritis
• Age between 50 and 70 years

Exclusion criteria

• Recent Lower limb injury
• Diabetic
• Knee or hip replacement
• Knees HA injection in last 6 months
• Any neuromuscular disease such as stroke and Parkinson

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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85 participants in 1 patient group

biomechanis knee OA and HA injection

Experimental group

Description:

Weekly intra- articular Hyaluronic acid injection (20 MG/ 2 ML) into both knees for five weeks

Treatment:

Other: Hyaluronic acid