Galactose Mediated Glycogen Resynthesis

University of Birmingham

Status: Completed

Conditions: Exercise

Treatments: Other: Glucose alone; Other: Glucose and galactose; Other: Galactose alone

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT03903861

ERN_19-0308

Details and patient eligibility

About

This study will compare short-term post-exercise muscle glycogen synthesis following combined galactose-glucose, glucose alone or galactose alone ingestion.

Full description

Lactose, the sugar contained within milk, consists of glucose and galactose. Post-exercise consumption of a carbohydrate mixture containing glucose with galactose has been shown to accelerate liver glycogen repletion as compared to glucose-only provision. However, the extent to which galactose-glucose combinations influence post-exercise muscle glycogen storage has yet to be determined.

Therefore, this study will investigate whether short-term muscle glycogen storage after strenuous endurance exercise is enhanced by combined galactose-glucose or glucose only ingestion as compared to the ingestion of galactose alone.

Enrollment: 9 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:.

• Body mass index in the range: 18.5 - 27.5 kg/m2
• Participates in endurance-based exercise (e.g. cycling, running, rowing) at least 3 times per week
• Aerobic fitness: VO2max >45 ml/kg/min (men), >40 ml/kg/min (women)

Exclusion Criteria:

• Lidocaine allergy
• Current participation in another scientific/clinical study
• Bleeding disorder/s
• Current or recent smoker to include vaping (last 60 days)
• Vegan
• Existence of food intolerances
• Poor recent health as indicated in the general health questionnaire
• Engage in uncommon eating practices (e.g. sustained periods of fasting)
• Diagnosed with galactosemia

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

---

9 participants in 3 patient groups

Glucose alone

Experimental group

Description:

Participants will complete a glycogen depleting bout of exercise followed by the provision of glucose-alone over 4 hours of recovery before a subsequent bout of exercise.

Treatment:

Other: Glucose alone

Galactose alone

Experimental group

Description:

Participants will complete a glycogen depleting bout of exercise followed by the provision of galactose-alone over 4 hours of recovery before a subsequent bout of exercise.

Treatment:

Other: Galactose alone

Glucose and galactose

Experimental group

Description:

Participants will complete a glycogen depleting bout of exercise followed by the provision of glucose and galactose over 4 hours of recovery before a subsequent bout of exercise.

Treatment:

Other: Glucose and galactose