Gas Exchange and CT Effects of PEEP in ARDS

Policlinico Hospital

Status: Completed

Conditions: ARDS

Treatments: Diagnostic Test: ALPE

Study type: Interventional

Funder types: Other

Identifiers

NCT04067154

2425

Details and patient eligibility

About

The study aims to investigate the association between effects of PEEP on gas exchange model parameters and CT scan results

Full description

In ARDS patients on mechanical ventilation, we will compare model-based estimation of gas exchange parameters (shunt, ventilation/perfusion mismatch) with CT-based estimation of effects of low and high PEEP

Enrollment: 13 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ARDS patients requiring mechanical ventilation

Exclusion criteria

• <18 years old
• Requirement of extracorporal life support
• Hemodynamic instability
• Barotrauma

Trial design

Primary purpose: Supportive Care

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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13 participants in 1 patient group

ALPE-TAC

Experimental group

Description:

ARDS patients on mechanical ventilation. Measurement of CT scan at PEEP of 5, 20 and 45 cm H2O to evaluate potential for recruitment and measurement of gas exchange by model-based method and FiO2 titration at PEEP of 5 and 20 cm H2O

Treatment:

Diagnostic Test: ALPE