Gasdermin D Expression in Generalized Vitiligo Patients After Narrow-band Ultraviolet B Therapy

South Valley University

Status: Not yet enrolling

Conditions: Vitiligo, Generalized

Treatments: Device: narrow band ultraviolet-B

Study type: Interventional

Funder types: Other

Identifiers

NCT06546059

SVU-MED-,4-24,7,871

Details and patient eligibility

About

The aim of this study is to:

1. Evaluate the role of tissue Gasdermin D expression using immunehistochemstry techniques in patients with generalized vitiligo and compare it with healthy controls.
2. Evaluation expression of tissue Gasdermin D using immunehistochemstry techniques in patients with generalized vitiligo after narrow band ultraviolet B therapy.
3. Determine whether there is a relationship between Gasdermin D levels and disease duration and involved body surface area (VISA) in vitiligo patients.

Full description

The aim of this study is to:

1. Evaluate the role of tissue Gasdermin D expression using immunehistochemstry techniques in patients with generalized vitiligo and compare it with healthy controls.
2. Evaluation expression of tissue Gasdermin D using immunehistochemstry techniques in patients with generalized vitiligo after narrow band ultraviolet B therapy.
3. Determine whether there is a relationship between Gasdermin D levels and disease duration and involved body surface area (VISA) in vitiligo patients.

Enrollment: 40 estimated patients

Sex: All

Ages: 10 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with stable vitiligo of 6 months duration,
• Both sex and ages(10-75)

Exclusion criteria

• pregnancy,
• lactation,
• patients under or previous phototherapy,
• patients on other immunosuppressives,
• patients receiving topical or systemic therapy like antioxidants and vitamins were kept off treatment for 2 weeks prior to recruitment into the study.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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40 participants in 1 patient group

one group

Other group

Treatment:

Device: narrow band ultraviolet-B