Gastric Cancer Survival Without Chemotherapy

Saint Vincent's Hospital, Korea

Status: Completed

Conditions: Gastric Cancer

Treatments: Other: No adjuvant chemotherapy

Study type: Observational

Funder types: Other

Identifiers

NCT05125614

apzzap2

Details and patient eligibility

About

This study is observational study to analyze the actual overall survival of the patients who did not receive adjuvant chemotherapy after curative gastrectomy for gastric cancer.

The investigators developed prediction model for the overall survival of these patients and validated.

Full description

Adjuvant chemotherapy (AC) after curative gastrectomy is the standard treatment for patients with locally advanced gastric adenocarcinoma in East Asia; however, for various reasons, some patients do not receive this treatment. The aim of this study was to develop a system that reflects the survival rate of patients without AC. A survival prediction model was developed based on the modified staging system and risk factors for overall survival (OS), which were examined using the Cox proportional hazards regression model. The model was validated for the power of prediction and discrimination, compared with the American Joint Committee on Cancer (AJCC) Cancer Staging Manual 8th edition; it was externally validated using an independent dataset. the newly developed survival prediction model improves the accuracy of OS prediction for stage II and III gastric cancer patients without AC after curative gastrectomy.

Enrollment: 342 patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• histologically confirmed primary gastric adenocarcinoma
• curative R0 resection with D2 lymph node dissection
• pathologic stage II or III gastric cancer

Exclusion criteria

• Patients who received neoadjuvant or AC treatment
• follow-up loss or death within 30 days of surgery
• completion of total gastrectomy
• other malignancy within 5 years before gastrectomy

Trial design

342 participants in 2 patient groups

Developement set

Description:

Gastric cancer patients who did not receive adjuvant chemotherapy after curative gastrectomy from 2009 to 2016 at Seoul St.Mary's Hospital

Treatment:

Other: No adjuvant chemotherapy

Validation set

Description:

Gastric cancer patients who did not receive adjuvant chemotherapy after curative gastrectomy from 2009 to 2016 at St.Vincent''s Hospital

Treatment:

Other: No adjuvant chemotherapy