Gastric Emptying and Insulin Response to Test Drink

Franco Carli

Status: Completed

Conditions: Insulin Resistance

Treatments: Other: Carbohydrate based drink; Other: Whey protein based drink

Study type: Interventional

Funder types: Other

Identifiers

NCT01971229

13-168-BMA

Details and patient eligibility

About

Surgery is a stress on the body and recovering well after surgery is very important to patients and their doctors. It is therefore important to prepare patient's bodies for the stress of surgery, and one way to do this is to provide proper nutrition. In the past, patients were asked to prepare for surgery by fasting from midnight before surgery. Today, it is known that this practice is not beneficial to patient's recovery. In fact, it has been recognized that drinking a sugary beverage (e.g., juice) before surgery stimulates the production of insulin, which is a hormone that helps make the proteins needed for wound healing after surgery. This is currently practiced at the MUHC. It might also be beneficial, however, to drink a beverage that contains sugar and whey proteins (a protein isolated from milk) before surgery. In fact, whey proteins stimulate insulin and may also have the added benefit of improving muscular strength. In this study, investigators will measure the level of insulin produced after drinking a carbohydrate (i.e., sugar)-whey protein beverage to determine how it compares to the level of insulin produced after drinking the sugary beverage used at the MUHC.

Full description

It is hypothesized that the increase in plasma insulin following a mixed carbohydrate whey protein drink is significantly greater than that elicited by a carbohydrate drink.

Enrollment: 15 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteer

Exclusion criteria

• diabetes,
• neurological disorders
• chronic kidney failure
• chronic liver disease
• disorders of gastric motility
• gastro-esophageal reflux
• achalasia
• gastroparesis
• intestinal obstruction
• previous abdominal surgery
• lactose intolerance
• body mass index below 17 or above 29
• allergy to acetaminophen.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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15 participants in 2 patient groups

Carbohydrate

Sham Comparator group

Description:

Patients in this arm will drink a 425 mL 100% clear apple juice (carbohydrate 50 g, 700 mOsmol). 1.5 g of acetaminophen will be dissolved in the beverage for determination of gastric emptying.

Treatment:

Other: Whey protein based drink

Other: Carbohydrate based drink

Whey Protein

Active Comparator group

Description:

Patients in this arm will drink a 330 mL Boost fruit flavoured clear beverage (whey protein 12.2 g, carbohydrate 50 g, 700 mOsmol).1.5 g of acetaminophen will be dissolved in the beverage for determination of gastric emptying.

Treatment:

Other: Whey protein based drink

Other: Carbohydrate based drink