Gastric Emptying in Elderly With Hip Fracture (GASEMPHIP)

U

Uppsala University

Status

Completed

Conditions

Mild Insufficient Nutrition
Gastroparesis
Hip Fracture

Treatments

Procedure: Gastric emptying of carbohydrate-rich beverage

Study type

Observational

Funder types

Other

Identifiers

NCT02753010
GASEMPHIP

Details and patient eligibility

About

The gastric emptying of 400 ml 12.6% carbohydrate rich drink is investigated in elderly women, age 75-100, with acute hip fracture. The emptying time will be assessed by the paracetamol absorption technique, and lag phase and gastric half-emptying time compared with two gender-matched reference groups: elective hip replacement patients, age 45-71, and healthy volunteers, age 28-55.

Full description

Patients with hip fracture are submitted to prolonged fasting before surgery is undertaken. This is deleterious for their metabolic condition and slows recovery after surgery. A carbohydrate-rich beverage is taken immediately before surgery and gastric emptying rate is assessed in elderly (75-100 yo) women prior to surgery for acute hip fracture. As comparator another two groups of women are used; one scheduled for elective surgery for hip replacement due to osteoarthritis; another healthy female volunteers. On the day of surgery the primary study group of acute hip fracture is given a carbohydrate-rich beverage 400 ml, total 200 kcal in combination with paracetamol 1.5 g. Blood samples are intermittently drawn during 180 minutes to measure recovery of paracetamol in plasma and gastric emptying rate calculated according to previously published principles. In the same manner a group of women on waiting list for hip replacement surgery due to osteoarthritis are enrolled for estimation of gastric emptying rate. In addition, another group of completely healthy women are enrolled for assessment of gastric emptying.

Enrollment

30 patients

Sex

Female

Ages

45 to 100 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

female gender, age 75 years or above, and hip fracture within 24 hours of admission.

Exclusion criteria

gastro-esophageal reflux disease, peptic ulcer disease, gastrointestinal motility disorder, pulmonary or cardiac disease, pharmacological treatment with motility-stimulating agents such as dopamine-receptor blockers or macrolides, as well as previous long-term opioids or acid inhibitory agents, or cognitive impairment at the discretion of the investigator

Trial design

30 participants in 3 patient groups

Acute hip fracture
Description:
Women preoperatively with acute hip fracture with gastric emptying of carbohydrate-rich beverage
Treatment:
Procedure: Gastric emptying of carbohydrate-rich beverage
Elective hip replacement
Description:
Women on waiting list for elective hip replacement with gastric emptying of carbohydrate-rich beverage
Treatment:
Procedure: Gastric emptying of carbohydrate-rich beverage
Healthy volunteers
Description:
Healthy female volunteers with gastric emptying of carbohydrate-rich beverage
Treatment:
Procedure: Gastric emptying of carbohydrate-rich beverage

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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